| 1. Round | 12/09/2021 | FC Schalke 04 [Youth] | - | 1. FC Köln [Youth] | 4:1 | ||||
| 2. Round | 19/09/2021 | Fortuna Düsseldorf [Youth] | - | FC Schalke 04 [Youth] | 0:1 | ||||
| 3. Round | 26/09/2021 | FC Schalke 04 [Youth] | - | Alemannia Aachen [Youth] | 5:0 |  |
|||
| 4. Round | 02/10/2021 | Bayer Leverkusen [Youth] | - | FC Schalke 04 [Youth] | 2:2 |  |
|||
| 5. Round | 17/10/2021 | FC Schalke 04 [Youth] | - | Wuppertaler SV [Youth] | 8:0 | |
|||
| 6. Round | 24/10/2021 | Borussia Dortmund [Youth] | - | FC Schalke 04 [Youth] | 4:0 | ||||
| 7. Round | 31/10/2021 | FC Schalke 04 [Youth] | - | Viktoria Köln [Youth] | 2:2 | ||||
| 8. Round | 28/11/2021 | Bor. Mönchengladbach [Youth] | - | FC Schalke 04 [Youth] | 1:1 | ||||
| 9. Round | 05/12/2021 | FC Schalke 04 [Youth] | - | VfL Bochum [Youth] | 0:1 | ||||
| 15. Round | 09/04/2022 | FC Schalke 04 [Youth] | - | MSV Duisburg [Youth] | 1:0 | ||||
| 16. Round | 23/04/2022 | Arminia Bielefeld [Youth] | - | FC Schalke 04 [Youth] | 0:3 | |
Germany