| 1. Round | 13/08/2022 | Bayer Leverkusen [Youth B] | - | Sportfreunde Siegen [Youth B] | 4:0 |  |
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| 2. Round | 20/08/2022 | Fortuna Düsseldorf [Youth B] | - | Bayer Leverkusen [Youth B] | 2:2 | |
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| 3. Round | 28/08/2022 | Bayer Leverkusen [Youth B] | - | Fortuna Köln [Youth B] | 7:0 | |
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| 4. Round | 03/09/2022 | Arminia Bielefeld [Youth B] | - | Bayer Leverkusen [Youth B] | 7:1 |  |
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| 5. Round | 10/09/2022 | Bayer Leverkusen [Youth B] | - | FC Schalke 04 [Youth B] | 0:1 | ||||
| 6. Round | 18/09/2022 | Bor. Mönchengladbach [Youth B] | - | Bayer Leverkusen [Youth B] | 2:1 | |
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| 7. Round | 02/10/2022 | Bayer Leverkusen [Youth B] | - | Preußen Münster [Youth B] | 4:0 | |
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| 8. Round | 09/10/2022 | SC Paderborn 07 [Youth B] | - | Bayer Leverkusen [Youth B] | 0:4 | |
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| 9. Round | 30/10/2022 | Bayer Leverkusen [Youth B] | - | Rot-Weiss Essen [Youth B] | 3:0 | |
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| 10. Round | 05/11/2022 | FC Hennef 05 [Youth B] | - | Bayer Leverkusen [Youth B] | 1:5 | |
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| 11. Round | 12/11/2022 | 1. FC Köln [Youth B] | - | Bayer Leverkusen [Youth B] | 2:4 | |
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| 12. Round | 19/11/2022 | Bayer Leverkusen [Youth B] | - | SV Deutz 05 [Youth B] | 3:1 | |
Germany
Nigeria