| 5. Round | 18/09/2021 | 1. FSV Mainz 05 | - | SC Freiburg | 0:0 | ||||
| 10. Round | 30/10/2021 | SC Freiburg | - | SpVgg Greuther Fürth | 3:1 | ||||
| 14. Round | 05/12/2021 | Bor. Mönchengladbach | - | SC Freiburg | 0:6 | ||||
| 15. Round | 11/12/2021 | SC Freiburg | - | 1899 Hoffenheim | 1:2 | ||||
| 16. Round | 15/12/2021 | 1. FC Union Berlin | - | SC Freiburg | 0:0 | ||||
| 17. Round | 19/12/2021 | SC Freiburg | - | Bayer Leverkusen | 2:1 | ||||
| 18. Round | 08/01/2022 | SC Freiburg | - | Arminia Bielefeld | 2:2 |  |
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| 24. Round | 26/02/2022 | SC Freiburg | - | Hertha BSC | 3:0 | ||||
| 25. Round | 05/03/2022 | RB Leipzig | - | SC Freiburg | 1:1 | ||||
| 26. Round | 12/03/2022 | SC Freiburg | - | VfL Wolfsburg | 3:2 | ||||
| 29. Round | 10/04/2022 | Eintracht Frankfurt | - | SC Freiburg | 1:2 | ||||
| 31. Round | 23/04/2022 | SC Freiburg | - | Bor. Mönchengladbach | 3:3 |
Germany