| 1. Round | 29/08/2021 | Viktoria Clarholz | - | Holzwickeder SC | 1:2 | ||||
| 2. Round | 05/09/2021 | Holzwickeder SC | - | TuS Ennepetal | 2:4 | ||||
| 3. Round | 12/09/2021 | SV Schermbeck | - | Holzwickeder SC | 2:3 | ||||
| 4. Round | 19/09/2021 | Holzwickeder SC | - | SG Wattenscheid 09 | 1:3 |  |
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| 5. Round | 26/09/2021 | FCE Rheine | - | Holzwickeder SC | 3:0 | ||||
| 6. Round | 03/10/2021 | Holzwickeder SC | - | TSG Sprockhövel | 0:5 | ||||
| 7. Round | 10/10/2021 | Hammer SpVg | - | Holzwickeder SC | 1:1 | ||||
| 8. Round | 17/10/2021 | Holzwickeder SC | - | Sportfreunde Siegen | 0:2 | ||||
| 9. Round | 24/10/2021 | SpVgg Vreden | - | Holzwickeder SC | 1:0 | ||||
| 10. Round | 31/10/2021 | Holzwickeder SC | - | FC Gütersloh | 1:3 | ||||
| 13. Round | 20/11/2021 | Preußen Münster II | - | Holzwickeder SC | 0:3 | ||||
| 14. Round | 25/11/2021 | Holzwickeder SC | - | SC Paderborn 07 II | 0:6 | ||||
| 15. Round | 05/12/2021 | RSV Meinerzhagen | - | Holzwickeder SC | 4:1 | ||||
| 16. Round | 12/12/2021 | Holzwickeder SC | - | Westfalia Herne | 1:1 | ||||
| 20. Round | 20/03/2022 | SG Finnentrop/Bamenohl | - | Holzwickeder SC | 2:0 | ||||
| 21. Round | 07/04/2022 | Holzwickeder SC | - | 1. FC Kaan-Marienborn | 1:1 |
Germany