1. Round | 14/08/2021 | Bonner SC | - | Rot-Weiss Essen | 0:3 | ||||
4. Round | 29/08/2021 | Rot-Weiss Essen | - | Fortuna Köln | 2:1 | ||||
6. Round | 10/09/2021 | Rot-Weiss Essen | - | VfB Homberg | 3:0 | ||||
7. Round | 14/09/2021 | Preußen Münster | - | Rot-Weiss Essen | 2:3 | ||||
8. Round | 17/09/2021 | Rot-Weiss Essen | - | FC Schalke 04 II | 1:0 | ||||
9. Round | 25/09/2021 | SV Lippstadt 08 | - | Rot-Weiss Essen | 1:2 | ||||
10. Round | 02/10/2021 | Rot-Weiss Essen | - | Rot-Weiß Oberhausen | 1:1 | ||||
12. Round | 16/10/2021 | Rot-Weiss Essen | - | SC Wiedenbrück | 0:0 |