| 3. Round | 26/09/2021 | SC Paderborn 07 [Youth] | - | Viktoria Köln [Youth] | 1:2 | ||||
| 5. Round | 16/10/2021 | SC Paderborn 07 [Youth] | - | VfL Bochum [Youth] | 1:2 |  |
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| 6. Round | 23/10/2021 | Preußen Münster [Youth] | - | SC Paderborn 07 [Youth] | 2:4 | ||||
| 7. Round | 31/10/2021 | SC Paderborn 07 [Youth] | - | Rot-Weiss Essen [Youth] | 3:4 |  |
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| 8. Round | 27/11/2021 | Rot-Weiß Oberhausen [Youth] | - | SC Paderborn 07 [Youth] | 1:0 | ||||
| 10. Round | 05/02/2022 | SC Paderborn 07 [Youth] | - | Fortuna Köln [Youth] | 4:0 | ||||
| 11. Round | 13/02/2022 | MSV Duisburg [Youth] | - | SC Paderborn 07 [Youth] | 0:0 | ||||
| 12. Round | 19/02/2022 | SC Paderborn 07 [Youth] | - | Arminia Bielefeld [Youth] | 3:2 | |
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| 13. Round | 05/03/2022 | FC Schalke 04 [Youth] | - | SC Paderborn 07 [Youth] | 1:0 | ||||
| 14. Round | 02/04/2022 | SC Paderborn 07 [Youth] | - | 1. FC Köln [Youth] | 0:0 | ||||
| 15. Round | 10/04/2022 | Fortuna Düsseldorf [Youth] | - | SC Paderborn 07 [Youth] | 0:2 | |
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| 16. Round | 23/04/2022 | SC Paderborn 07 [Youth] | - | Alemannia Aachen [Youth] | 3:1 | |
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| 17. Round | 30/04/2022 | Bayer Leverkusen [Youth] | - | SC Paderborn 07 [Youth] | 2:2 |
Germany