| 1. Round | 22/08/2021 | 1. FC Kleve | - | TSV Meerbusch | 2:1 | ||||
| 2. Round | 29/08/2021 | 1. FC Bocholt | - | 1. FC Kleve | 2:2 | ||||
| 3. Round | 05/09/2021 | 1. FC Kleve | - | SSVg Velbert | 0:0 | ||||
| 6. Round | 26/09/2021 | Schwarz-Weiß Essen | - | 1. FC Kleve | 0:1 | ||||
| 7. Round | 03/10/2021 | 1. FC Kleve | - | FC Kray | 4:4 | ||||
| 8. Round | 10/10/2021 | DJK Teutonia St. Tönis | - | 1. FC Kleve | 1:2 | ||||
| 12. Round | 07/11/2021 | 1. FC Mönchengladbach | - | 1. FC Kleve | 1:2 | ||||
| 13. Round | 14/11/2021 | 1. FC Kleve | - | FSV Duisburg | 1:1 | ||||
| 14. Round | 28/11/2021 | VfB 03 Hilden | - | 1. FC Kleve | 4:0 | ||||
| 15. Round | 03/12/2021 | 1. FC Kleve | - | SC Velbert | 8:0 |  |
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| 16. Round | 12/12/2021 | Sportfreunde Niederwenigern | - | 1. FC Kleve | 1:4 | ||||
| 18. Round | 22/02/2022 | SpVg Schonnebeck | - | 1. FC Kleve | 2:3 | ||||
| 19. Round | 25/02/2022 | 1. FC Kleve | - | Cronenberger SC | 3:1 | ||||
| 21. Round | 11/03/2022 | 1. FC Kleve | - | SC Düsseldorf-West | 2:2 | ||||
| 22. Round | 20/03/2022 | Sportfreunde Baumberg | - | 1. FC Kleve | 2:1 | ||||
| 20. Round | 23/03/2022 | SC Union Nettetal | - | 1. FC Kleve | 1:0 |  |
Uganda