| Group B | 14/09/2010 | Olympique Lyonnais | - | FC Schalke 04 | 1:0 | ||||
| Group B | 29/09/2010 | FC Schalke 04 | - | SL Benfica | 2:0 |  |
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| Group B | 20/10/2010 | FC Schalke 04 | - | Hapoel Tel Aviv | 3:1 | ||||
| Group B | 02/11/2010 | Hapoel Tel Aviv | - | FC Schalke 04 | 0:0 |  |
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| Group B | 24/11/2010 | FC Schalke 04 | - | Olympique Lyonnais | 3:0 | |
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| Group B | 07/12/2010 | SL Benfica | - | FC Schalke 04 | 1:2 | |
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| Round of 16 | 15/02/2011 | Valencia CF | - | FC Schalke 04 | 1:1 | ||||
| Semi-finals | 04/05/2011 | Manchester United | - | FC Schalke 04 | 4:1 |
Netherlands
