| 13. Round | 31/10/2021 | SpVg Frechen 20 | - | 1. FC Düren | 3:1 | ||||
| 19. Round | 24/02/2022 | SpVg Frechen 20 | - | Blau-Weiß Friesdorf | 0:1 | ||||
| 18. Round | 27/02/2022 | Borussia Freialdenhoven | - | SpVg Frechen 20 | 1:1 | ||||
| 20. Round | 06/03/2022 | SV Bergisch Gladbach 09 | - | SpVg Frechen 20 | 5:1 | ||||
| 21. Round | 13/03/2022 | SpVg Frechen 20 | - | SV 1914 Eilendorf | 2:0 | ||||
| 22. Round | 20/03/2022 | Viktoria Arnoldsweiler | - | SpVg Frechen 20 | 2:1 | ||||
| 23. Round | 27/03/2022 | SpVg Frechen 20 | - | Siegburger SV 04 | 4:3 | ||||
| 24. Round | 03/04/2022 | Spvg Wesseling-Urfeld | - | SpVg Frechen 20 | 1:3 | ||||
| 25. Round | 10/04/2022 | SpVg Frechen 20 | - | SV Breinig | 6:1 | ||||
| 26. Round | 18/04/2022 | BC Viktoria Glesch-Paffendorf | - | SpVg Frechen 20 | 0:1 | ||||
| 28. Round | 01/05/2022 | VfL Alfter | - | SpVg Frechen 20 | 0:1 | ||||
| 29. Round | 08/05/2022 | SpVg Frechen 20 | - | SV Deutz 05 | 3:1 | ||||
| 30. Round | 15/05/2022 | 1. FC Düren | - | SpVg Frechen 20 | 5:0 | ||||
| 31. Round | 22/05/2022 | SpVg Frechen 20 | - | Fortuna Köln II | 1:4 | ||||
| 33. Round | 06/06/2022 | SpVg Frechen 20 | - | FC Hürth | 0:3 |
Germany