| 2. Round | 05/09/2021 | TuS Haltern | - | SpVgg Vreden | 1:1 | ||||
| 3. Round | 12/09/2021 | SpVgg Vreden | - | TuS Erndtebrück | 1:1 | ||||
| 4. Round | 19/09/2021 | Preußen Münster II | - | SpVgg Vreden | 4:2 | ||||
| 5. Round | 26/09/2021 | SpVgg Vreden | - | SC Paderborn 07 II | 0:5 | ||||
| 6. Round | 03/10/2021 | RSV Meinerzhagen | - | SpVgg Vreden | 0:1 | ||||
| 7. Round | 10/10/2021 | SpVgg Vreden | - | Westfalia Herne | 3:2 |  |
|||
| 8. Round | 17/10/2021 | Westfalia Rhynern | - | SpVgg Vreden | 6:0 | ||||
| 10. Round | 31/10/2021 | ASC 09 Dortmund | - | SpVgg Vreden | 4:2 | ||||
| 11. Round | 07/11/2021 | SpVgg Vreden | - | SG Finnentrop/Bamenohl | 1:1 | ||||
| 12. Round | 14/11/2021 | 1. FC Kaan-Marienborn | - | SpVgg Vreden | 1:0 | ||||
| 15. Round | 05/12/2021 | SpVgg Vreden | - | SV Schermbeck | 0:3 |
Netherlands
Turkey