| 1. Round | 22/08/2021 | SpVg Schonnebeck | - | Schwarz-Weiß Essen | 5:0 | ||||
| 5. Round | 19/09/2021 | SpVg Schonnebeck | - | Germania Ratingen 04/19 | 0:2 | ||||
| 6. Round | 26/09/2021 | 1. FC Monheim | - | SpVg Schonnebeck | 1:1 | ||||
| 7. Round | 03/10/2021 | SpVg Schonnebeck | - | 1. FC Mönchengladbach | 2:2 | ||||
| 8. Round | 10/10/2021 | FSV Duisburg | - | SpVg Schonnebeck | 1:2 | ||||
| 9. Round | 27/10/2021 | SpVg Schonnebeck | - | VfB 03 Hilden | 0:2 | ||||
| 11. Round | 31/10/2021 | SpVg Schonnebeck | - | Sportfreunde Niederwenigern | 2:2 | ||||
| 17. Round | 18/12/2021 | Sportfreunde Baumberg | - | SpVg Schonnebeck | 2:2 |
Germany