1. Round | 15/08/2021 | Willem II | - | Feyenoord | 0:4 | ||||
2. Round | 22/08/2021 | Vitesse | - | Willem II | 0:3 | ||||
3. Round | 28/08/2021 | Willem II | - | PEC Zwolle | 1:0 | ||||
4. Round | 12/09/2021 | NEC Nijmegen | - | Willem II | 0:0 | ||||
5. Round | 18/09/2021 | Willem II | - | FC Groningen | 2:1 | ||||
6. Round | 21/09/2021 | RKC Waalwijk | - | Willem II | 1:2 | ||||
7. Round | 25/09/2021 | Willem II | - | PSV Eindhoven | 2:1 | ||||
8. Round | 02/10/2021 | Heracles Almelo | - | Willem II | 3:2 | ||||
9. Round | 17/10/2021 | FC Twente | - | Willem II | 1:1 | ||||
10. Round | 22/10/2021 | Willem II | - | Fortuna Sittard | 1:1 | ||||
11. Round | 31/10/2021 | FC Utrecht | - | Willem II | 5:1 | ||||
12. Round | 06/11/2021 | Willem II | - | Sparta Rotterdam | 0:3 | ||||
13. Round | 21/11/2021 | sc Heerenveen | - | Willem II | 2:1 | ||||
14. Round | 27/11/2021 | Willem II | - | Go Ahead Eagles | 0:1 | ||||
16. Round | 10/12/2021 | Willem II | - | SC Cambuur | 1:3 | ||||
17. Round | 18/12/2021 | AZ Alkmaar | - | Willem II | 4:1 | ||||
18. Round | 22/12/2021 | Willem II | - | NEC Nijmegen | 0:1 | ||||
19. Round | 14/01/2022 | PEC Zwolle | - | Willem II | 2:0 |