| 7. Round | 17/10/2021 | Borussia Bocholt [Women] | - | RB Leipzig [Women] | 1:9 | ||||
| 8. Round | 07/11/2021 | RB Leipzig [Women] | - | SV 07 Elversberg [Women] | 3:0 | ||||
| 10. Round | 21/11/2021 | 1. FC Nürnberg [Women] | - | RB Leipzig [Women] | 4:3 | ||||
| 12. Round | 12/12/2021 | FSV Gütersloh 2009 [Women] | - | RB Leipzig [Women] | 1:4 | ||||
| 9. Round | 15/12/2021 | FC Ingolstadt 04 [Women] | - | RB Leipzig [Women] | 2:3 | ||||
| 13. Round | 19/12/2021 | RB Leipzig [Women] | - | MSV Duisburg [Women] | 3:0 | ||||
| 11. Round | 13/02/2022 | SV Henstedt-Ulzburg [Women] | - | RB Leipzig [Women] | 2:3 | ||||
| 14. Round | 27/02/2022 | RB Leipzig [Women] | - | VfL Wolfsburg II [Women] | 0:0 | ||||
| 15. Round | 06/03/2022 | 1899 Hoffenheim II [Women] | - | RB Leipzig [Women] | 0:3 | ||||
| 16. Round | 13/03/2022 | RB Leipzig [Women] | - | Bayern München II [Women] | 2:3 | ||||
| 20. Round | 17/04/2022 | RB Leipzig [Women] | - | Borussia Bocholt [Women] | 3:2 |  |
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| 26. Round | 05/06/2022 | MSV Duisburg [Women] | - | RB Leipzig [Women] | 6:1 |
Germany