| 1. Round | 22/08/2021 | SC Velbert | - | TuRU Düsseldorf | 4:1 | ||||
| 4. Round | 12/09/2021 | 1. FC Mönchengladbach | - | SC Velbert | 0:4 | ||||
| 5. Round | 18/09/2021 | SC Velbert | - | FSV Duisburg | 2:0 |  |
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| 6. Round | 26/09/2021 | VfB 03 Hilden | - | SC Velbert | 3:3 | ||||
| 10. Round | 24/10/2021 | SC Velbert | - | SpVg Schonnebeck | 1:3 | ||||
| 13. Round | 14/11/2021 | SC Düsseldorf-West | - | SC Velbert | 2:0 | ||||
| 14. Round | 27/11/2021 | SC Velbert | - | Sportfreunde Baumberg | 0:3 | ||||
| 16. Round | 11/12/2021 | SC Velbert | - | TSV Meerbusch | 2:3 | ||||
| 17. Round | 18/12/2021 | 1. FC Bocholt | - | SC Velbert | 5:0 | ||||
| 19. Round | 26/02/2022 | TVD Velbert | - | SC Velbert | 2:0 | ||||
| 20. Round | 06/03/2022 | SC Velbert | - | SpVgg Sterkrade-Nord | 3:1 | ||||
| 21. Round | 13/03/2022 | Schwarz-Weiß Essen | - | SC Velbert | 8:0 | ||||
| 18. Round | 16/03/2022 | SC Velbert | - | SSVg Velbert | 0:5 | ||||
| 23. Round | 27/03/2022 | DJK Teutonia St. Tönis | - | SC Velbert | 0:0 |
Germany