| 1. Round | 28/07/2018 | TSG Balingen | - | 1. FSV Mainz 05 II | 2:0 | ||||
| 2. Round | 04/08/2018 | 1. FSV Mainz 05 II | - | FK Pirmasens | 0:1 | ||||
| 3. Round | 07/08/2018 | Kickers Offenbach | - | 1. FSV Mainz 05 II | 0:1 | ||||
| 4. Round | 11/08/2018 | 1. FSV Mainz 05 II | - | Wormatia Worms | 2:0 | ||||
| 5. Round | 17/08/2018 | FC 08 Homburg | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 6. Round | 25/08/2018 | 1. FSV Mainz 05 II | - | SV 07 Elversberg | 0:0 | ||||
| 8. Round | 08/09/2018 | 1. FSV Mainz 05 II | - | VfB Stuttgart II | 2:3 | ||||
| 9. Round | 14/09/2018 | 1. FSV Mainz 05 II | - | SSV Ulm 1846 | 4:1 |  |
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| 10. Round | 23/09/2018 | 1899 Hoffenheim II | - | 1. FSV Mainz 05 II | 3:0 | ||||
| 12. Round | 05/10/2018 | FSV Frankfurt | - | 1. FSV Mainz 05 II | 0:0 | ||||
| 14. Round | 20/10/2018 | 1. FC Saarbrücken | - | 1. FSV Mainz 05 II | 3:2 |  |
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| 13. Round | 06/11/2018 | 1. FSV Mainz 05 II | - | SC Freiburg II | 0:0 | ||||
| 17. Round | 10/11/2018 | 1. FSV Mainz 05 II | - | Waldhof Mannheim | 0:3 | ||||
| 18. Round | 25/11/2018 | 1. FSV Mainz 05 II | - | TSG Balingen | 2:2 | ||||
| 19. Round | 01/12/2018 | FK Pirmasens | - | 1. FSV Mainz 05 II | 0:0 | |
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| 29. Round | 12/04/2019 | 1. FSV Mainz 05 II | - | FSV Frankfurt | 2:0 |
Germany