| 1. Round | 22/08/2021 | SC Union Nettetal | - | TVD Velbert | 1:2 | ||||
| 2. Round | 29/08/2021 | TVD Velbert | - | SC Düsseldorf-West | 2:1 | ||||
| 3. Round | 05/09/2021 | Sportfreunde Baumberg | - | TVD Velbert | 0:1 | ||||
| 4. Round | 12/09/2021 | TVD Velbert | - | 1. FC Kleve | 1:0 |  |
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| 5. Round | 19/09/2021 | TSV Meerbusch | - | TVD Velbert | 2:1 | ||||
| 6. Round | 26/09/2021 | TVD Velbert | - | 1. FC Bocholt | 3:3 |  |
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| 12. Round | 07/11/2021 | DJK Teutonia St. Tönis | - | TVD Velbert | 2:0 |  |
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| 13. Round | 14/11/2021 | TVD Velbert | - | TuRU Düsseldorf | 4:2 | |
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| 14. Round | 28/11/2021 | Germania Ratingen 04/19 | - | TVD Velbert | 1:2 | ||||
| 16. Round | 11/12/2021 | 1. FC Mönchengladbach | - | TVD Velbert | 1:1 | |
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| 17. Round | 18/12/2021 | TVD Velbert | - | FSV Duisburg | 3:1 |
Germany