| 1. Round | 07/08/2005 | Hansa Rostock | - | Kickers Offenbach | 1:2 |  |
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| 2. Round | 14/08/2005 | Kickers Offenbach | - | SpVgg Greuther Fürth | 2:1 | ||||
| 3. Round | 26/08/2005 | Dynamo Dresden | - | Kickers Offenbach | 4:1 | ||||
| 4. Round | 11/09/2005 | Kickers Offenbach | - | SC Freiburg | 2:1 | ||||
| 5. Round | 16/09/2005 | Kickers Offenbach | - | TSV 1860 München | 2:5 | ||||
| 6. Round | 20/09/2005 | Eintracht Braunschweig | - | Kickers Offenbach | 2:0 | ||||
| 8. Round | 02/10/2005 | SC Paderborn 07 | - | Kickers Offenbach | 4:1 |  |
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| 9. Round | 16/10/2005 | Kickers Offenbach | - | Sportfreunde Siegen | 1:1 | ||||
| 10. Round | 21/10/2005 | Alemannia Aachen | - | Kickers Offenbach | 0:1 | ||||
| 11. Round | 30/10/2005 | Kickers Offenbach | - | Wacker Burghausen | 1:3 | ||||
| 14. Round | 27/11/2005 | SpVgg Unterhaching | - | Kickers Offenbach | 2:0 | |
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| 15. Round | 04/12/2005 | Kickers Offenbach | - | 1. FC Saarbrücken | 2:3 |
Germany