| 8. Round | 09/10/2021 | Energie Cottbus [Youth B] | - | Hannover 96 [Youth B] | 2:1 | ||||
| 9. Round | 16/10/2021 | Dynamo Dresden [Youth B] | - | Energie Cottbus [Youth B] | 5:0 | ||||
| 10. Round | 06/11/2021 | Energie Cottbus [Youth B] | - | FC Viktoria 1889 Berlin [Youth B] | 2:1 |  |
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| 11. Round | 20/11/2021 | Erzgebirge Aue [Youth B] | - | Energie Cottbus [Youth B] | 2:2 |  |
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| 5. Round | 23/02/2022 | FC Carl Zeiss Jena [Youth B] | - | Energie Cottbus [Youth B] | 2:0 | ||||
| 12. Round | 02/03/2022 | Energie Cottbus [Youth B] | - | RB Leipzig [Youth B] | 0:6 | ||||
| 15. Round | 06/03/2022 | Energie Cottbus [Youth B] | - | Hertha BSC [Youth B] | 1:1 | ||||
| 13. Round | 26/03/2022 | FC St. Pauli [Youth B] | - | Energie Cottbus [Youth B] | 2:0 | ||||
| 17. Round | 02/04/2022 | Energie Cottbus [Youth B] | - | Eintracht Braunschweig [Youth B] | 3:0 |
Germany