| 1. Round | 11/09/2021 | SC Paderborn 07 [Youth] | - | Wuppertaler SV [Youth] | 1:1 | ||||
| 5. Round | 17/10/2021 | FC Schalke 04 [Youth] | - | Wuppertaler SV [Youth] | 8:0 |  |
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| 7. Round | 30/10/2021 | Fortuna Düsseldorf [Youth] | - | Wuppertaler SV [Youth] | 0:2 | |
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| 11. Round | 13/02/2022 | Wuppertaler SV [Youth] | - | Borussia Dortmund [Youth] | 0:4 | ||||
| 12. Round | 20/02/2022 | Viktoria Köln [Youth] | - | Wuppertaler SV [Youth] | 4:0 | ||||
| 13. Round | 05/03/2022 | Wuppertaler SV [Youth] | - | Bor. Mönchengladbach [Youth] | 1:1 |
Germany