| 6. Round | 11/09/2021 | Bischofswerdaer FV | - | FC Grimma | 3:1 | ||||
| 7. Round | 19/09/2021 | FC Grimma | - | FC Einheit Rudolstadt | 3:0 | ||||
| 8. Round | 26/09/2021 | Wacker Nordhausen | - | FC Grimma | 3:2 | ||||
| 10. Round | 17/10/2021 | 1. FC Merseburg | - | FC Grimma | annull. | ||||
| 19. Round | 26/03/2022 | FC Grimma | - | VFC Plauen | 1:2 | ||||
| 21. Round | 02/04/2022 | FSV Budissa Bautzen | - | FC Grimma | 2:0 | ||||
| 32. Round | 12/06/2022 | SV 09 Arnstadt | - | FC Grimma | 4:1 |
Germany