| 1. Round | 12/08/2018 | FCE Rheine | - | SC Paderborn 07 II | 5:3 | ||||
| 2. Round | 19/08/2018 | SC Paderborn 07 II | - | 1. FC Gievenbeck | 3:0 | ||||
| 3. Round | 25/08/2018 | SC Paderborn 07 II | - | FC Schalke 04 II | 1:4 | ||||
| 4. Round | 02/09/2018 | TuS Haltern | - | SC Paderborn 07 II | 2:0 | ||||
| 5. Round | 09/09/2018 | SC Paderborn 07 II | - | TuS Ennepetal | 2:2 | ||||
| 6. Round | 16/09/2018 | Hammer SpVg | - | SC Paderborn 07 II | 4:2 | ||||
| 7. Round | 23/09/2018 | SC Paderborn 07 II | - | FC Brünninghausen | 1:0 | ||||
| 8. Round | 30/09/2018 | TSG Sprockhövel | - | SC Paderborn 07 II | 2:4 | ||||
| 11. Round | 21/10/2018 | SC Paderborn 07 II | - | Sportfreunde Siegen | 3:3 |
Germany