| 1. Round | 29/08/2021 | TuS Ennepetal | - | Westfalia Rhynern | 3:2 | ||||
| 2. Round | 05/09/2021 | Holzwickeder SC | - | TuS Ennepetal | 2:4 | ||||
| 3. Round | 12/09/2021 | TuS Ennepetal | - | ASC 09 Dortmund | 2:3 | ||||
| 4. Round | 19/09/2021 | SG Finnentrop/Bamenohl | - | TuS Ennepetal | 3:3 |  |
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| 13. Round | 20/11/2021 | Sportfreunde Siegen | - | TuS Ennepetal | 3:3 | ||||
| 14. Round | 28/11/2021 | TuS Ennepetal | - | SpVgg Vreden | 0:2 | ||||
| 15. Round | 05/12/2021 | FC Gütersloh | - | TuS Ennepetal | 2:0 | ||||
| 17. Round | 20/02/2022 | TuS Erndtebrück | - | TuS Ennepetal | 3:2 | ||||
| 16. Round | 27/02/2022 | TuS Ennepetal | - | TuS Haltern | 0:5 | ||||
| 18. Round | 06/03/2022 | TuS Ennepetal | - | Preußen Münster II | 2:1 | ||||
| 21. Round | 27/03/2022 | Westfalia Herne | - | TuS Ennepetal | 1:5 | ||||
| 20. Round | 07/04/2022 | TuS Ennepetal | - | RSV Meinerzhagen | 0:3 |
Germany