| 1. Round | 29/08/2021 | Viktoria Clarholz | - | Holzwickeder SC | 1:2 | ||||
| 2. Round | 05/09/2021 | Holzwickeder SC | - | TuS Ennepetal | 2:4 |  |
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| 3. Round | 12/09/2021 | SV Schermbeck | - | Holzwickeder SC | 2:3 | |
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| 4. Round | 19/09/2021 | Holzwickeder SC | - | SG Wattenscheid 09 | 1:3 | |
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| 10. Round | 31/10/2021 | Holzwickeder SC | - | FC Gütersloh | 1:3 | |
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| 11. Round | 07/11/2021 | TuS Haltern | - | Holzwickeder SC | 0:1 | ||||
| 12. Round | 14/11/2021 | Holzwickeder SC | - | TuS Erndtebrück | 0:6 | ||||
| 17. Round | 09/03/2022 | Westfalia Rhynern | - | Holzwickeder SC | 2:0 | ||||
| 19. Round | 13/03/2022 | Holzwickeder SC | - | ASC 09 Dortmund | 1:5 | ||||
| 20. Round | 20/03/2022 | SG Finnentrop/Bamenohl | - | Holzwickeder SC | 2:0 |
Germany