| 1. Round | 08/08/2021 | US Hostert | - | FC Rodange 91 | 3:1 | ||||
| 3. Round | 22/08/2021 | US Hostert | - | FC Wiltz 71 | 1:3 | ||||
| 4. Round | 28/08/2021 | F91 Dudelange | - | US Hostert | 2:2 | ||||
| 5. Round | 12/09/2021 | US Hostert | - | Jeunesse Esch | 0:3 |  |
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| 6. Round | 17/09/2021 | Progrès Niedercorn | - | US Hostert | 3:1 |  |
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| 7. Round | 22/09/2021 | RFCU Luxemburg | - | US Hostert | 7:0 | ||||
| 8. Round | 26/09/2021 | US Hostert | - | Union Titus Pétange | 0:1 | |
Luxembourg