| 10. Round | 05/02/2022 | SC Paderborn 07 [Youth] | - | Fortuna Köln [Youth] | 4:0 | ||||
| 11. Round | 13/02/2022 | MSV Duisburg [Youth] | - | SC Paderborn 07 [Youth] | 0:0 | ||||
| 12. Round | 19/02/2022 | SC Paderborn 07 [Youth] | - | Arminia Bielefeld [Youth] | 3:2 | ||||
| 13. Round | 05/03/2022 | FC Schalke 04 [Youth] | - | SC Paderborn 07 [Youth] | 1:0 | ||||
| 14. Round | 02/04/2022 | SC Paderborn 07 [Youth] | - | 1. FC Köln [Youth] | 0:0 | ||||
| 15. Round | 10/04/2022 | Fortuna Düsseldorf [Youth] | - | SC Paderborn 07 [Youth] | 0:2 | ||||
| 16. Round | 23/04/2022 | SC Paderborn 07 [Youth] | - | Alemannia Aachen [Youth] | 3:1 | ||||
| 17. Round | 30/04/2022 | Bayer Leverkusen [Youth] | - | SC Paderborn 07 [Youth] | 2:2 |
Germany