| 8. Round | 26/09/2021 | FC Pesch 1956 | - | FC Hennef 05 | 0:2 | ||||
| 9. Round | 06/10/2021 | FC Hennef 05 | - | VfL Alfter | 4:1 | ||||
| 16. Round | 28/11/2021 | FC Hennef 05 | - | Borussia Freialdenhoven | 4:0 | ||||
| 18. Round | 20/02/2022 | SV Bergisch Gladbach 09 | - | FC Hennef 05 | 1:0 | ||||
| 19. Round | 23/02/2022 | FC Hennef 05 | - | SV 1914 Eilendorf | 1:0 | ||||
| 20. Round | 06/03/2022 | Viktoria Arnoldsweiler | - | FC Hennef 05 | 1:4 |  |
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| 21. Round | 13/03/2022 | FC Hennef 05 | - | Siegburger SV 04 | 0:0 | ||||
| 22. Round | 20/03/2022 | Spvg Wesseling-Urfeld | - | FC Hennef 05 | 1:4 | ||||
| 23. Round | 27/03/2022 | FC Hennef 05 | - | SV Breinig | 3:2 | |
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| 24. Round | 03/04/2022 | BC Viktoria Glesch-Paffendorf | - | FC Hennef 05 | 0:4 | |
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| 25. Round | 10/04/2022 | FC Hennef 05 | - | FC Pesch 1956 | 6:0 | |
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| 26. Round | 18/04/2022 | VfL Alfter | - | FC Hennef 05 | 1:2 | ||||
| 28. Round | 01/05/2022 | 1. FC Düren | - | FC Hennef 05 | 5:1 | |
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| 29. Round | 08/05/2022 | FC Hennef 05 | - | Fortuna Köln II | 4:3 | |
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| 30. Round | 15/05/2022 | FC Hennef 05 | - | VfL 08 Vichttal | 5:1 | |
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| 34. Round | 12/06/2022 | FC Hennef 05 | - | Blau-Weiß Friesdorf | 2:1 | |
Germany