| 1. Round | 15/08/2021 | Hertha Zehlendorf [Youth B] | - | FC St. Pauli [Youth B] | 0:1 | ||||
| 2. Round | 22/08/2021 | FC St. Pauli [Youth B] | - | Hansa Rostock [Youth B] | 2:1 | ||||
| 4. Round | 11/09/2021 | FC St. Pauli [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 4:0 | ||||
| 9. Round | 30/10/2021 | FC Viktoria 1889 Berlin [Youth B] | - | FC St. Pauli [Youth B] | 0:1 | ||||
| 10. Round | 06/11/2021 | FC St. Pauli [Youth B] | - | Erzgebirge Aue [Youth B] | 5:0 | ||||
| 14. Round | 26/02/2022 | Hertha BSC [Youth B] | - | FC St. Pauli [Youth B] | 2:0 | ||||
| 15. Round | 05/03/2022 | FC St. Pauli [Youth B] | - | VfL Wolfsburg [Youth B] | 1:1 | ||||
| 11. Round | 08/03/2022 | RB Leipzig [Youth B] | - | FC St. Pauli [Youth B] | 1:2 | ||||
| 13. Round | 26/03/2022 | FC St. Pauli [Youth B] | - | Energie Cottbus [Youth B] | 2:0 | ||||
| 17. Round | 02/04/2022 | FC St. Pauli [Youth B] | - | Werder Bremen [Youth B] | 2:1 | ||||
| 16. Round | 05/04/2022 | Eintracht Braunschweig [Youth B] | - | FC St. Pauli [Youth B] | 0:2 | ||||
| 18. Round | 09/04/2022 | Holstein Kiel [Youth B] | - | FC St. Pauli [Youth B] | 0:1 |
Germany