| 2. Round | 03/08/2024 | FC Schalke 04 II | - | KFC Uerdingen 05 | annull. |  |
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| 3. Round | 09/08/2024 | FC Schalke 04 II | - | SV Rödinghausen | 2:2 | ||||
| 4. Round | 17/08/2024 | 1. FC Bocholt | - | FC Schalke 04 II | 3:1 | ||||
| 5. Round | 24/08/2024 | FC Schalke 04 II | - | 1. FC Düren | 1:4 | |
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| 6. Round | 01/09/2024 | 1. FC Köln II | - | FC Schalke 04 II | 4:0 | ||||
| 7. Round | 14/09/2024 | FC Schalke 04 II | - | Bor. Mönchengladbach II | 0:1 | ||||
| 8. Round | 20/09/2024 | Wuppertaler SV | - | FC Schalke 04 II | 1:0 | ||||
| 10. Round | 05/10/2024 | Sportfreunde Lotte | - | FC Schalke 04 II | 4:1 | ||||
| 19. Round | 25/01/2025 | KFC Uerdingen 05 | - | FC Schalke 04 II | annull. | ||||
| 20. Round | 01/02/2025 | SV Rödinghausen | - | FC Schalke 04 II | 0:0 | ||||
| 21. Round | 08/02/2025 | FC Schalke 04 II | - | 1. FC Bocholt | 0:0 | ||||
| 22. Round | 15/02/2025 | 1. FC Düren | - | FC Schalke 04 II | 1:1 | ||||
| 24. Round | 28/02/2025 | Bor. Mönchengladbach II | - | FC Schalke 04 II | 0:0 | ||||
| 25. Round | 08/03/2025 | FC Schalke 04 II | - | Wuppertaler SV | 1:0 | ||||
| 26. Round | 14/03/2025 | MSV Duisburg | - | FC Schalke 04 II | 4:0 | |
Germany