| 1. Round | 25/07/2022 | SV Wehen Wiesbaden | - | Borussia Dortmund II | 1:1 | ||||
| 2. Round | 06/08/2022 | Viktoria Köln | - | SV Wehen Wiesbaden | 1:0 | ||||
| 3. Round | 10/08/2022 | SV Wehen Wiesbaden | - | SpVgg Bayreuth | 4:1 |  |
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| 4. Round | 14/08/2022 | Erzgebirge Aue | - | SV Wehen Wiesbaden | 1:5 | ||||
| 5. Round | 20/08/2022 | SV Wehen Wiesbaden | - | VfL Osnabrück | 1:1 | ||||
| 6. Round | 27/08/2022 | FC Ingolstadt 04 | - | SV Wehen Wiesbaden | 2:3 | ||||
| 8. Round | 10/09/2022 | SV Wehen Wiesbaden | - | SC Freiburg II | 3:1 |  |
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| 9. Round | 17/09/2022 | Waldhof Mannheim | - | SV Wehen Wiesbaden | 1:0 | ||||
| 10. Round | 02/10/2022 | SV Wehen Wiesbaden | - | Rot-Weiss Essen | 3:1 | ||||
| 11. Round | 08/10/2022 | FSV Zwickau | - | SV Wehen Wiesbaden | 0:1 |  |
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| 13. Round | 22/10/2022 | TSV 1860 München | - | SV Wehen Wiesbaden | 3:1 | ||||
| 21. Round | 04/02/2023 | SV Wehen Wiesbaden | - | Viktoria Köln | 1:1 | ||||
| 23. Round | 17/02/2023 | SV Wehen Wiesbaden | - | Erzgebirge Aue | 1:2 | ||||
| 24. Round | 25/02/2023 | VfL Osnabrück | - | SV Wehen Wiesbaden | 4:1 | ||||
| 25. Round | 04/03/2023 | SV Wehen Wiesbaden | - | FC Ingolstadt 04 | 4:1 |
Germany