| 2. Round | 22/08/2021 | FV Bad Vilbel | - | SC Waldgirmes | 2:2 |  |
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| 3. Round | 28/08/2021 | SC Waldgirmes | - | SV Rot-Weiss Hadamar | 2:2 | ||||
| 4. Round | 01/09/2021 | Türk Gücü Friedberg | - | SC Waldgirmes | 1:3 | ||||
| 5. Round | 06/09/2021 | Rot-Weiß Walldorf | - | SC Waldgirmes | 2:0 | ||||
| 6. Round | 11/09/2021 | SC Waldgirmes | - | FC Eddersheim | 1:0 | |
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| 7. Round | 15/09/2021 | SC Waldgirmes | - | FV Bad Vilbel | 3:1 | ||||
| 8. Round | 19/09/2021 | SV Zeilsheim | - | SC Waldgirmes | 1:5 | |
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| 1. Round | 22/09/2021 | SC Waldgirmes | - | Türk Gücü Friedberg | 2:2 | ||||
| 10. Round | 29/09/2021 | SV Rot-Weiss Hadamar | - | SC Waldgirmes | 2:1 | ||||
| 11. Round | 02/10/2021 | Viktoria Griesheim | - | SC Waldgirmes | 1:3 | |
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| 12. Round | 09/10/2021 | SC Waldgirmes | - | TuS Dietkirchen | 3:4 | |
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| 16. Round | 30/10/2021 | SC Waldgirmes | - | Hessen Dreieich | 4:2 | |
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| 18. Round | 13/11/2021 | TuS Dietkirchen | - | SC Waldgirmes | 2:2 | |
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| 19. Round | 20/11/2021 | SC Waldgirmes | - | Viktoria Griesheim | 2:0 | ||||
| 20. Round | 28/11/2021 | VfB Ginsheim | - | SC Waldgirmes | 3:2 | |
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| 21. Round | 04/12/2021 | SC Waldgirmes | - | SV Zeilsheim | 1:0 |
Germany