| 1. Round | 13/08/2021 | Hertha BSC [Youth] | - | VfL Wolfsburg [Youth] | 2:1 |  |
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| 2. Round | 21/08/2021 | VfL Wolfsburg [Youth] | - | 1. FC Magdeburg [Youth] | 2:1 |  |
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| 3. Round | 11/09/2021 | 1. FC Union Berlin [Youth] | - | VfL Wolfsburg [Youth] | 2:2 | ||||
| 4. Round | 18/09/2021 | VfL Wolfsburg [Youth] | - | Hannover 96 [Youth] | 1:1 | ||||
| 5. Round | 25/09/2021 | Hansa Rostock [Youth] | - | VfL Wolfsburg [Youth] | 2:2 | |
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| 6. Round | 02/10/2021 | VfL Wolfsburg [Youth] | - | Energie Cottbus [Youth] | 0:1 | ||||
| 7. Round | 16/10/2021 | Hamburger SV [Youth] | - | VfL Wolfsburg [Youth] | 0:1 | ||||
| 8. Round | 23/10/2021 | VfL Wolfsburg [Youth] | - | FC St. Pauli [Youth] | 2:2 | |
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| 9. Round | 30/10/2021 | FC Carl Zeiss Jena [Youth] | - | VfL Wolfsburg [Youth] | 1:3 | |
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| 15. Round | 05/03/2022 | Dynamo Dresden [Youth] | - | VfL Wolfsburg [Youth] | 0:1 | ||||
| 12. Round | 12/03/2022 | VfL Wolfsburg [Youth] | - | RB Leipzig [Youth] | 0:1 | ||||
| 16. Round | 02/04/2022 | VfL Wolfsburg [Youth] | - | FC Viktoria 1889 Berlin [Youth] | 1:0 | ||||
| 17. Round | 09/04/2022 | Hallescher FC [Youth] | - | VfL Wolfsburg [Youth] | 0:1 | ||||
| 19. Round | 30/04/2022 | VfL Wolfsburg [Youth] | - | Werder Bremen [Youth] | 1:1 |
Japan