| 2. Round | 05/09/2021 | SC Paderborn 07 II | - | TSG Sprockhövel | 4:0 | ||||
| 4. Round | 19/09/2021 | SC Paderborn 07 II | - | Sportfreunde Siegen | 3:1 | ||||
| 5. Round | 26/09/2021 | SpVgg Vreden | - | SC Paderborn 07 II | 0:5 | ||||
| 6. Round | 03/10/2021 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 | ||||
| 7. Round | 10/10/2021 | TuS Haltern | - | SC Paderborn 07 II | 2:5 | ||||
| 8. Round | 17/10/2021 | SC Paderborn 07 II | - | TuS Erndtebrück | 5:0 | ||||
| 9. Round | 23/10/2021 | Preußen Münster II | - | SC Paderborn 07 II | 0:4 | ||||
| 12. Round | 14/11/2021 | Westfalia Herne | - | SC Paderborn 07 II | 1:2 | ||||
| 13. Round | 20/11/2021 | SC Paderborn 07 II | - | Westfalia Rhynern | 0:3 | ||||
| 14. Round | 25/11/2021 | Holzwickeder SC | - | SC Paderborn 07 II | 0:6 | ||||
| 11. Round | 08/12/2021 | SC Paderborn 07 II | - | RSV Meinerzhagen | 5:1 | ||||
| 16. Round | 12/12/2021 | SG Finnentrop/Bamenohl | - | SC Paderborn 07 II | 2:2 |
Germany