| 1. Round | 12/09/2021 | FC Schalke 04 [Youth] | - | 1. FC Köln [Youth] | 4:1 | ||||
| 3. Round | 26/09/2021 | FC Schalke 04 [Youth] | - | Alemannia Aachen [Youth] | 5:0 | ||||
| 4. Round | 02/10/2021 | Bayer Leverkusen [Youth] | - | FC Schalke 04 [Youth] | 2:2 |  |
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| 6. Round | 24/10/2021 | Borussia Dortmund [Youth] | - | FC Schalke 04 [Youth] | 4:0 | ||||
| 7. Round | 31/10/2021 | FC Schalke 04 [Youth] | - | Viktoria Köln [Youth] | 2:2 | ||||
| 10. Round | 06/02/2022 | Preußen Münster [Youth] | - | FC Schalke 04 [Youth] | 1:3 | ||||
| 11. Round | 13/02/2022 | FC Schalke 04 [Youth] | - | Rot-Weiss Essen [Youth] | 1:2 |
Germany