| 5. Round | 25/09/2021 | VfB Stuttgart [Youth] | - | SSV Ulm 1846 [Youth] | 3:1 |  |
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| 6. Round | 02/10/2021 | Bayern München [Youth] | - | VfB Stuttgart [Youth] | 1:4 | ||||
| 8. Round | 24/10/2021 | 1. FC Saarbrücken [Youth] | - | VfB Stuttgart [Youth] | 0:1 | |
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| 10. Round | 20/11/2021 | VfB Stuttgart [Youth] | - | Eintracht Frankfurt [Youth] | 3:0 | ||||
| 11. Round | 27/11/2021 | 1899 Hoffenheim [Youth] | - | VfB Stuttgart [Youth] | 2:2 | |
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| 12. Round | 04/12/2021 | VfB Stuttgart [Youth] | - | Hessen Kassel [Youth] | 7:0 | ||||
| 13. Round | 05/02/2022 | 1. FC Nürnberg [Youth] | - | VfB Stuttgart [Youth] | 0:2 | ||||
| 14. Round | 13/02/2022 | VfB Stuttgart [Youth] | - | SpVgg Greuther Fürth [Youth] | 5:1 | |
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| 15. Round | 20/02/2022 | 1. FSV Mainz 05 [Youth] | - | VfB Stuttgart [Youth] | 0:3 | ||||
| 16. Round | 25/02/2022 | VfB Stuttgart [Youth] | - | Karlsruher SC [Youth] | 0:1 | ||||
| 17. Round | 04/03/2022 | FC-Astoria Walldorf [Youth] | - | VfB Stuttgart [Youth] | 3:0 | ||||
| 18. Round | 02/04/2022 | VfB Stuttgart [Youth] | - | FC Ingolstadt 04 [Youth] | 6:1 | |
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| 19. Round | 10/04/2022 | SpVgg Unterhaching [Youth] | - | VfB Stuttgart [Youth] | 1:0 |
Portugal