| 5. Round | 18/09/2005 | Hansa Rostock | - | SC Paderborn 07 | 2:0 | ||||
| 6. Round | 21/09/2005 | SC Paderborn 07 | - | SpVgg Greuther Fürth | 1:2 | ||||
| 7. Round | 25/09/2005 | Dynamo Dresden | - | SC Paderborn 07 | 0:2 | ||||
| 8. Round | 02/10/2005 | SC Paderborn 07 | - | Kickers Offenbach | 4:1 | ||||
| 9. Round | 14/10/2005 | TSV 1860 München | - | SC Paderborn 07 | 1:0 | ||||
| 10. Round | 21/10/2005 | SC Paderborn 07 | - | Eintracht Braunschweig | 3:0 | ||||
| 11. Round | 28/10/2005 | VfL Bochum | - | SC Paderborn 07 | 1:1 | ||||
| 12. Round | 06/11/2005 | SC Paderborn 07 | - | SC Freiburg | 1:1 | ||||
| 13. Round | 18/11/2005 | SC Paderborn 07 | - | Sportfreunde Siegen | 4:0 | ||||
| 14. Round | 27/11/2005 | Alemannia Aachen | - | SC Paderborn 07 | 2:1 | ||||
| 15. Round | 04/12/2005 | SC Paderborn 07 | - | Wacker Burghausen | 1:3 | ||||
| 16. Round | 09/12/2005 | Erzgebirge Aue | - | SC Paderborn 07 | 1:0 | ||||
| 17. Round | 19/12/2005 | SC Paderborn 07 | - | Karlsruher SC | 2:0 |
Germany