| 4. Round | 27/08/2010 | FSV Frankfurt II | - | SSV Ulm 1846 | annull. | ||||
| 5. Round | 01/09/2010 | SC Freiburg II | - | FSV Frankfurt II | 1:4 | ||||
| 6. Round | 04/09/2010 | FSV Frankfurt II | - | Hessen Kassel | 1:4 | ||||
| 7. Round | 11/09/2010 | Karlsruher SC II | - | FSV Frankfurt II | 1:1 | ||||
| 8. Round | 18/09/2010 | FSV Frankfurt II | - | SpVgg Greuther Fürth II | 0:1 | ||||
| 10. Round | 25/09/2010 | FSV Frankfurt II | - | SpVgg Weiden | annull. | ||||
| 9. Round | 28/09/2010 | Eintracht Frankfurt II | - | FSV Frankfurt II | 1:0 |  |
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| 12. Round | 16/10/2010 | FC Memmingen | - | FSV Frankfurt II | 1:0 | |
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| 13. Round | 19/10/2010 | FSV Frankfurt II | - | SC Pfullendorf | 3:1 | ||||
| 14. Round | 31/10/2010 | SG Sonnenhof Großaspach | - | FSV Frankfurt II | 1:1 | ||||
| 15. Round | 06/11/2010 | FSV Frankfurt II | - | SV Darmstadt 98 | 0:1 | ||||
| 16. Round | 13/11/2010 | Stuttgarter Kickers | - | FSV Frankfurt II | 7:2 |  |
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| 18. Round | 26/11/2010 | TSV 1860 München II | - | FSV Frankfurt II | 1:1 | ||||
| 22. Round | 26/02/2011 | FSV Frankfurt II | - | SC Freiburg II | 2:2 | ||||
| 33. Round | 21/05/2011 | FSV Frankfurt II | - | Stuttgarter Kickers | 0:2 | ||||
| 34. Round | 28/05/2011 | 1. FC Nürnberg II | - | FSV Frankfurt II | 2:3 |
Germany