| 1. Round | 29/07/2000 | Eintracht Trier | - | Kickers Offenbach | 2:2 | ||||
| 2. Round | 04/08/2000 | Kickers Offenbach | - | Rot-Weiß Erfurt | 0:1 |  |
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| 4. Round | 18/08/2000 | Kickers Offenbach | - | VfR Mannheim | 0:2 | ||||
| 6. Round | 02/09/2000 | Kickers Offenbach | - | SC Pfullendorf | 3:1 | ||||
| 9. Round | 23/09/2000 | Kickers Offenbach | - | SV Wehen-Taunusstein | 1:2 | ||||
| 21. Round | 24/02/2001 | VfR Mannheim | - | Kickers Offenbach | 0:3 | ||||
| 22. Round | 04/03/2001 | Kickers Offenbach | - | VfB Stuttgart II | 1:1 | ||||
| 23. Round | 10/03/2001 | SC Pfullendorf | - | Kickers Offenbach | 1:1 | ||||
| 24. Round | 17/03/2001 | 1. FC Schweinfurt 05 | - | Kickers Offenbach | 0:1 | |
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| 25. Round | 31/03/2001 | Kickers Offenbach | - | VfR Aalen | 1:1 | ||||
| 26. Round | 08/04/2001 | SV Wehen-Taunusstein | - | Kickers Offenbach | 1:2 | ||||
| 27. Round | 14/04/2001 | Kickers Offenbach | - | FC Carl Zeiss Jena | 4:1 |  |
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| 28. Round | 20/04/2001 | Sportfreunde Siegen | - | Kickers Offenbach | 0:1 | ||||
| 29. Round | 28/04/2001 | Kickers Offenbach | - | TSV 1860 München II | 2:2 |  |
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| 33. Round | 23/05/2001 | Kickers Offenbach | - | Wacker Burghausen | 0:0 | ||||
| 34. Round | 26/05/2001 | Jahn Regensburg | - | Kickers Offenbach | 1:4 |
Germany