| 6. Round | 04/09/2010 | Wormatia Worms | - | SC Freiburg II | 0:5 | ||||
| 14. Round | 29/10/2010 | TSV 1860 München II | - | SC Freiburg II | 0:3 | ||||
| 15. Round | 07/11/2010 | SC Freiburg II | - | SV Wehen Wiesbaden II | 1:3 | ||||
| 16. Round | 13/11/2010 | SSV Ulm 1846 | - | SC Freiburg II | annull. |  |
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| 17. Round | 21/11/2010 | SC Freiburg II | - | SpVgg Weiden | annull. | ||||
| 18. Round | 07/12/2010 | SC Freiburg II | - | Karlsruher SC II | 2:1 | |
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| 20. Round | 11/12/2010 | SC Freiburg II | - | Eintracht Frankfurt II | 0:3 | ||||
| 19. Round | 19/02/2011 | Hessen Kassel | - | SC Freiburg II | 3:1 |  |
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| 22. Round | 26/02/2011 | FSV Frankfurt II | - | SC Freiburg II | 2:2 | ||||
| 23. Round | 05/03/2011 | SC Freiburg II | - | Wormatia Worms | 1:2 | ||||
| 24. Round | 12/03/2011 | FC Memmingen | - | SC Freiburg II | 1:0 | ||||
| 27. Round | 10/04/2011 | SC Freiburg II | - | SV Darmstadt 98 | 1:2 | |
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| 30. Round | 29/04/2011 | 1899 Hoffenheim II | - | SC Freiburg II | 1:1 | ||||
| 31. Round | 06/05/2011 | SC Freiburg II | - | TSV 1860 München II | 5:3 | ||||
| 32. Round | 15/05/2011 | SV Wehen Wiesbaden II | - | SC Freiburg II | 2:7 |
Germany