| 31. Round | 10/04/2021 | Eintracht Stadtallendorf | - | 1. FSV Mainz 05 II | 3:2 | ||||
| 38. Round | 16/05/2021 | 1. FSV Mainz 05 II | - | VfR Aalen | 3:1 | ||||
| 39. Round | 22/05/2021 | FK Pirmasens | - | 1. FSV Mainz 05 II | 2:0 |  |
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| 40. Round | 29/05/2021 | Bahlinger SC | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 41. Round | 05/06/2021 | 1. FSV Mainz 05 II | - | SG Sonnenhof Großaspach | 0:1 | |
Germany