| 7. Round | 11/09/2010 | Karlsruher SC II | - | FSV Frankfurt II | 1:1 |  |
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| 8. Round | 18/09/2010 | FSV Frankfurt II | - | SpVgg Greuther Fürth II | 0:1 | ||||
| 10. Round | 25/09/2010 | FSV Frankfurt II | - | SpVgg Weiden | annull. | ||||
| 9. Round | 28/09/2010 | Eintracht Frankfurt II | - | FSV Frankfurt II | 1:0 |  |
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| 11. Round | 06/10/2010 | FSV Frankfurt II | - | Wormatia Worms | 2:0 | |
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| 13. Round | 19/10/2010 | FSV Frankfurt II | - | SC Pfullendorf | 3:1 | ||||
| 15. Round | 06/11/2010 | FSV Frankfurt II | - | SV Darmstadt 98 | 0:1 | ||||
| 16. Round | 13/11/2010 | Stuttgarter Kickers | - | FSV Frankfurt II | 7:2 | ||||
| 19. Round | 05/12/2010 | FSV Frankfurt II | - | 1899 Hoffenheim II | 1:3 | ||||
| 23. Round | 05/03/2011 | Hessen Kassel | - | FSV Frankfurt II | 1:0 | ||||
| 24. Round | 12/03/2011 | FSV Frankfurt II | - | Karlsruher SC II | 1:4 | |
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| 25. Round | 19/03/2011 | SpVgg Greuther Fürth II | - | FSV Frankfurt II | 2:1 | |
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| 21. Round | 06/04/2011 | FSV Frankfurt II | - | SV Wehen Wiesbaden II | 0:0 | ||||
| 31. Round | 04/05/2011 | FSV Frankfurt II | - | SG Sonnenhof Großaspach | 0:2 | ||||
| 32. Round | 13/05/2011 | SV Darmstadt 98 | - | FSV Frankfurt II | 2:0 | |
Germany