| 4. Round | 21/08/2021 | SC Paderborn 07 | - | FC St. Pauli | 3:1 | ||||
| 5. Round | 29/08/2021 | Dynamo Dresden | - | SC Paderborn 07 | 0:3 | ||||
| 6. Round | 12/09/2021 | SC Paderborn 07 | - | FC Schalke 04 | 0:1 | ||||
| 7. Round | 19/09/2021 | Erzgebirge Aue | - | SC Paderborn 07 | 1:4 |  |
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| 8. Round | 25/09/2021 | SC Paderborn 07 | - | Holstein Kiel | 1:2 | ||||
| 9. Round | 02/10/2021 | Fortuna Düsseldorf | - | SC Paderborn 07 | 2:3 | ||||
| 10. Round | 15/10/2021 | SC Paderborn 07 | - | Jahn Regensburg | 1:1 | ||||
| 12. Round | 31/10/2021 | Karlsruher SC | - | SC Paderborn 07 | 2:4 | ||||
| 18. Round | 18/12/2021 | SC Paderborn 07 | - | 1. FC Heidenheim 1846 | 1:2 | ||||
| 19. Round | 15/01/2022 | 1. FC Nürnberg | - | SC Paderborn 07 | 1:2 |  |
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| 21. Round | 05/02/2022 | FC St. Pauli | - | SC Paderborn 07 | 2:2 | |
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| 22. Round | 12/02/2022 | SC Paderborn 07 | - | Dynamo Dresden | 0:0 | ||||
| 23. Round | 18/02/2022 | FC Schalke 04 | - | SC Paderborn 07 | 2:0 | ||||
| 24. Round | 25/02/2022 | SC Paderborn 07 | - | Erzgebirge Aue | 3:3 | ||||
| 26. Round | 12/03/2022 | SC Paderborn 07 | - | Fortuna Düsseldorf | 1:1 | ||||
| 27. Round | 20/03/2022 | Jahn Regensburg | - | SC Paderborn 07 | 1:0 | |
Germany