| 14. Round | 27/02/2022 | SV Henstedt-Ulzburg [Women] | - | 1899 Hoffenheim II [Women] | 1:1 | ||||
| 15. Round | 06/03/2022 | 1899 Hoffenheim II [Women] | - | RB Leipzig [Women] | 0:3 | ||||
| 16. Round | 13/03/2022 | MSV Duisburg [Women] | - | 1899 Hoffenheim II [Women] | 1:1 |  |
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| 20. Round | 16/04/2022 | 1899 Hoffenheim II [Women] | - | Eintracht Frankfurt II [Women] | 1:1 | ||||
| 21. Round | 24/04/2022 | SV Meppen [Women] | - | 1899 Hoffenheim II [Women] | 1:0 | ||||
| 25. Round | 22/05/2022 | FC Ingolstadt 04 [Women] | - | 1899 Hoffenheim II [Women] | 2:1 | ||||
| 26. Round | 05/06/2022 | 1899 Hoffenheim II [Women] | - | 1. FC Nürnberg [Women] | 4:1 | |
Germany