| 5. Round | 04/09/2021 | SV Rot-Weiss Hadamar | - | Hessen Dreieich | 3:1 | ||||
| 6. Round | 10/09/2021 | Hessen Dreieich | - | Rot-Weiß Walldorf | 1:0 | ||||
| 7. Round | 15/09/2021 | Hessen Dreieich | - | Türk Gücü Friedberg | 3:0 | ||||
| 8. Round | 19/09/2021 | FC Eddersheim | - | Hessen Dreieich | 2:1 | ||||
| 9. Round | 24/09/2021 | Hessen Dreieich | - | SV Zeilsheim | 1:3 |  |
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| 10. Round | 29/09/2021 | FV Bad Vilbel | - | Hessen Dreieich | 1:3 | ||||
| 11. Round | 03/10/2021 | VfB Ginsheim | - | Hessen Dreieich | 3:3 | ||||
| 17. Round | 05/11/2021 | Hessen Dreieich | - | TuS Dietkirchen | 2:1 |
Germany