| 3. Round | 12/09/2021 | TuS Ennepetal | - | ASC 09 Dortmund | 2:3 | ||||
| 4. Round | 19/09/2021 | SG Finnentrop/Bamenohl | - | TuS Ennepetal | 3:3 | ||||
| 5. Round | 26/09/2021 | TuS Ennepetal | - | 1. FC Kaan-Marienborn | 0:3 | ||||
| 6. Round | 03/10/2021 | Viktoria Clarholz | - | TuS Ennepetal | 0:1 | ||||
| 9. Round | 22/10/2021 | SG Wattenscheid 09 | - | TuS Ennepetal | 1:0 | ||||
| 10. Round | 31/10/2021 | TuS Ennepetal | - | FCE Rheine | 4:1 | ||||
| 11. Round | 05/11/2021 | TSG Sprockhövel | - | TuS Ennepetal | 5:2 |  |
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| 12. Round | 14/11/2021 | TuS Ennepetal | - | Hammer SpVg | 2:2 | ||||
| 13. Round | 20/11/2021 | Sportfreunde Siegen | - | TuS Ennepetal | 3:3 | |
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| 15. Round | 05/12/2021 | FC Gütersloh | - | TuS Ennepetal | 2:0 | |
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| 17. Round | 20/02/2022 | TuS Erndtebrück | - | TuS Ennepetal | 3:2 |
Germany