| 11. Round | 09/10/2021 | FC Karbach | - | SG Mülheim-Kärlich | 2:1 | ||||
| 13. Round | 22/10/2021 | SG Mülheim-Kärlich | - | TuS Koblenz | 2:3 | ||||
| 14. Round | 27/10/2021 | FV Engers 07 | - | SG Mülheim-Kärlich | 1:1 | ||||
| 15. Round | 30/10/2021 | 1. FC Kaiserslautern II | - | SG Mülheim-Kärlich | 2:1 | ||||
| 16. Round | 05/11/2021 | SG Mülheim-Kärlich | - | TSV Emmelshausen | 3:2 | ||||
| 12. Round | 10/11/2021 | FSV Salmrohr | - | SG Mülheim-Kärlich | 0:1 | ||||
| 17. Round | 13/11/2021 | SV Alemannia Waldalgesheim | - | SG Mülheim-Kärlich | 2:1 |  |
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| 20. Round | 27/11/2021 | SG Mülheim-Kärlich | - | Sportfreunde Eisbachtal | 3:1 | ||||
| 21. Round | 26/02/2022 | SV Gonsenheim | - | SG Mülheim-Kärlich | 3:0 | ||||
| 22. Round | 05/03/2022 | SG Mülheim-Kärlich | - | FC Karbach | 0:0 |
Germany