| 1. Round | 28/08/2021 | SpVgg Vreden | - | FC Gütersloh | 0:2 | ||||
| 3. Round | 12/09/2021 | FC Gütersloh | - | TuS Haltern | 0:0 | ||||
| 4. Round | 19/09/2021 | TuS Erndtebrück | - | FC Gütersloh | 3:0 | ||||
| 6. Round | 03/10/2021 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 | ||||
| 7. Round | 10/10/2021 | FC Gütersloh | - | RSV Meinerzhagen | 3:0 |  |
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| 8. Round | 17/10/2021 | Westfalia Herne | - | FC Gütersloh | 1:2 | ||||
| 18. Round | 06/03/2022 | FCE Rheine | - | FC Gütersloh | 0:2 |
Germany