| 5. Round | 22/08/2021 | SV Zulte Waregem | - | Sporting Charleroi | 2:2 | ||||
| 6. Round | 28/08/2021 | Sporting Charleroi | - | K Beerschot VA | 5:2 |  |
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| 7. Round | 12/09/2021 | KAA Gent | - | Sporting Charleroi | 2:3 | ||||
| 13. Round | 30/10/2021 | Sporting Charleroi | - | KAS Eupen | 3:0 | ||||
| 14. Round | 06/11/2021 | Union Saint-Gilloise | - | Sporting Charleroi | 4:0 | ||||
| 21. Round | 27/12/2021 | Sporting Charleroi | - | Oud-Heverlee Leuven | 0:3 | ||||
| 29. Round | 25/02/2022 | K Beerschot VA | - | Sporting Charleroi | 2:3 | ||||
| 31. Round | 12/03/2022 | KV Mechelen | - | Sporting Charleroi | 2:2 | ||||
| 32. Round | 19/03/2022 | Sporting Charleroi | - | Cercle Brugge | 5:0 | |
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| 33. Round | 03/04/2022 | RSC Anderlecht | - | Sporting Charleroi | 4:0 | ||||
| 34. Round | 10/04/2022 | Sporting Charleroi | - | SV Zulte Waregem | 3:0 |
Belgium