| 5. Round | 09/10/2021 | Preußen Münster [Youth B] | - | Borussia Dortmund [Youth B] | 1:3 | ||||
| 6. Round | 31/10/2021 | Fortuna Düsseldorf [Youth B] | - | Preußen Münster [Youth B] | 5:1 | ||||
| 7. Round | 07/11/2021 | Preußen Münster [Youth B] | - | Arminia Bielefeld [Youth B] | 1:0 | ||||
| 8. Round | 27/11/2021 | Bayer Leverkusen [Youth B] | - | Preußen Münster [Youth B] | 2:3 |  |
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| 10. Round | 12/12/2021 | VfL Bochum [Youth B] | - | Preußen Münster [Youth B] | 4:3 | ||||
| 9. Round | 13/02/2022 | Preußen Münster [Youth B] | - | SV Lippstadt 08 [Youth B] | 3:0 | ||||
| 12. Round | 27/02/2022 | Preußen Münster [Youth B] | - | Alemannia Aachen [Youth B] | 2:0 | ||||
| 13. Round | 06/03/2022 | Fortuna Köln [Youth B] | - | Preußen Münster [Youth B] | 1:0 | ||||
| 16. Round | 09/04/2022 | Preußen Münster [Youth B] | - | SC Paderborn 07 [Youth B] | 1:5 |  |
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Germany