| 5. Round | 04/09/2021 | Sportfreunde Eisbachtal | - | FC Karbach | 0:3 | ||||
| 6. Round | 12/09/2021 | FSV Salmrohr | - | Sportfreunde Eisbachtal | 2:5 | ||||
| 7. Round | 18/09/2021 | Sportfreunde Eisbachtal | - | TuS Koblenz | 2:2 | ||||
| 8. Round | 22/09/2021 | FV Engers 07 | - | Sportfreunde Eisbachtal | 2:1 | ||||
| 9. Round | 25/09/2021 | Sportfreunde Eisbachtal | - | SG Mülheim-Kärlich | 1:1 | ||||
| 10. Round | 01/10/2021 | TSV Emmelshausen | - | Sportfreunde Eisbachtal | 2:0 | ||||
| 11. Round | 09/10/2021 | Sportfreunde Eisbachtal | - | SV Alemannia Waldalgesheim | 3:1 | ||||
| 12. Round | 16/10/2021 | Sportfreunde Eisbachtal | - | Eintracht Trier | 4:4 |  |
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| 13. Round | 23/10/2021 | Hassia Bingen | - | Sportfreunde Eisbachtal | 2:3 | ||||
| 14. Round | 27/10/2021 | Sportfreunde Eisbachtal | - | 1. FC Kaiserslautern II | 0:0 | ||||
| 15. Round | 30/10/2021 | Sportfreunde Eisbachtal | - | SV Gonsenheim | 2:2 | ||||
| 18. Round | 20/11/2021 | TuS Koblenz | - | Sportfreunde Eisbachtal | 2:1 | ||||
| 19. Round | 24/11/2021 | Sportfreunde Eisbachtal | - | FV Engers 07 | 1:2 | ||||
| 20. Round | 27/11/2021 | SG Mülheim-Kärlich | - | Sportfreunde Eisbachtal | 3:1 |
Japan