| 7. Round | 10/10/2021 | Hammer SpVg | - | Holzwickeder SC | 1:1 | ||||
| 8. Round | 17/10/2021 | Holzwickeder SC | - | Sportfreunde Siegen | 0:2 | ||||
| 9. Round | 24/10/2021 | SpVgg Vreden | - | Holzwickeder SC | 1:0 | ||||
| 10. Round | 31/10/2021 | Holzwickeder SC | - | FC Gütersloh | 1:3 | ||||
| 17. Round | 09/03/2022 | Westfalia Rhynern | - | Holzwickeder SC | 2:0 | ||||
| 19. Round | 13/03/2022 | Holzwickeder SC | - | ASC 09 Dortmund | 1:5 | ||||
| 20. Round | 20/03/2022 | SG Finnentrop/Bamenohl | - | Holzwickeder SC | 2:0 | ||||
| 21. Round | 07/04/2022 | Holzwickeder SC | - | 1. FC Kaan-Marienborn | 1:1 |
Germany